Risk factors for types of recurrent tuberculosis (reactivation versus reinfection): A global systematic review and meta-analysis

Risk factors for types of recurrent tuberculosis (reactivation versus reinfection): A global systematic review and meta-analysis

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Background: The purpose of this meta-analysis (PROSPERO number: CRD42021243204) is to perform extensive and penetrating analyses on the risk factors associated with reactivation or reinfection.Methods: We searched PubMed and Embase using search terms.Risk factors (including gender, length of time between first onset and recurrent diagnosis, extrapulmonary tuberculosis, sputum smear, pulmonary Course a pied - Homme - Vetements - Short - 3-4" cavity, Beijing family strains, diabetes, HIV infection, history of imprisonment, and immigration) were analyzed.The pooled risk ratio (RR) and 95% confidence interval (CI) were calculated with STATA 15.1.

Heterogeneity was evaluated by I2 and P values.Results: The meta-analysis included 25 studies with a total of 1,477 recurrent patients.After subgroup analysis, sensitivity analysis, and testing for publication bias, it was concluded that time spanning less than two years (RR = 1.56, 95% CI: 1.33-1.

85) was a risk factor for endogenous reactivation, whereas coinfection with HIV (RR = 0.72, 95% CI: 0.63-0.83), Beijing family genotype (RR = 0.46, 95% CI: 0.

32-0.67), history of imprisonment (RR = 0.36, 95% CI: 0.16-0.81), and immigration (RR = 0.

66, 95% CI: 0.53-0.82) were associated with exogenous reinfection.Conclusions: CACAO MIX CORDYCEPS The recurrence interval is a risk factor for the endogenous reactivation of tuberculosis.Infection with Beijing family strains, coinfection with HIV, imprisonment, and immigration contribute to the risk of exogenous reinfection.